SeerPharma Pty Ltd :: DISCover web-based training :: Introduction to Biopharma: Methods

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Introduction to Biopharma: Methods

Description: This course introduces genomics and combinatorial chemistry. This course introduces the human genome and the concepts of proteomics and bioinformatics, covers the different ways in which genomic-derived information may be used, and explains how genomics will influence new drug discovery.

COURSE OUTLINE

INTRODUCTION
1. Course Information
2. Interface Tour
3. Course Overview

THE GENOME
4. Objectives
5. Chromosomal Structure
6. DNA Structure
7. Pharmacogenomics
8. Progress Check

GENOMICS APPLICATIONS
9. Objectives
10. Applications of the HGI
11. Proteomics
12. Gene Therapy Targets
13. Bioinformatics
14. Progress Check

GENOMICS-BASED DRUG DISCOVERY
15. Objectives
16. Drug Targets
17. Medicinal Chemistry
18. Combinatorial Chemistry
19. High-Throughput Screening
20. Progress Check

CONCLUSION
21. Summary

COURSE OBJECTIVES

Students completing this course should be able to:

Specify the structure of human chromatin at five different levels of resolution
Describe the structure of DNA
Define what a SNP is
Explain the fundamental principle of pharmacogenomics
List four ways in which genomics information is used to generate new therapeutic agents
Explain the types of information that proteomics will generate
List three gene therapy approaches that utilize novel genes to target diseases
Understand the concept of bioinformatics
List four different types of cellular drug targets
Define the two technologies that allow the creation of large combinatorial libraries
Specify two of the features of an assay that make it amenable to high-throughput screening
Understand how the combination of high throughput screening and combinatorial chemistry has accelerated drug discovery

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