SeerPharma Pty Ltd :: DISCover web-based training :: Introduction to Biopharma: Basics

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Introduction to Biopharma: Applications

Description: This course describes computer-assisted drug design, introduces protein-based therapeutic agents, and describes the type of approaches used to treat immune-related diseases. This course describes the use of computer-based methods for designing new drugs and optimizing drug libraries and leads, introduces the design and use of protein based therapeutic agents, and introduces the immune system and immune related diseases.

COURSE OUTLINE

INTRODUCTION
1. Course Information
2. Interface Tour
3. Course Overview

COMPUTER-ASSISTED DRUG DESIGN (CADD)
4. Objectives
5. CADD Overview
6. Drug Pharmacophores
7. Library Design
8. Lead Optimization
9. Progress Check

PROTEIN THERAPEUTICS
10. Objectives
11. Protein Design
12. Protein Engineering
13. Antibody Structure
14. Therapeutic Peptides
15. Monoclonal Antibodies
16. Antibody Engineering
17. Antibody Therapeutics
18. Progress Check

IMMUNITY AND DISEASE
19. Objectives
20. Immunity and Disease
21. Immune Response
22. Vaccines
23. Vaccine Examples
24. Applications-Influenza
25. Applications-Autoimmune Disease
26. Progress Check

CONCLUSION
27. Summary

COURSE OBJECTIVES

Students completing this course should be able to:

Define a drug pharmacophore and describe its key features
List three of the parameters involved in designing combinatorial libraries
Define which two parameters in drug optimization can be improved by design
Give two examples of drugs that have been synthesized by solid-phase combinatorial synthesis
Specify three major applications of protein design
Define what site-directed mutagenesis is and how it is utilized
Describe how peptidomimetics are designed
Explain how monoclonal antibodies are generated
Specify which parts of an antibody molecule are modified to humanize it
List three ways in which antibodies are utilized for therapeutic purposes
Specify the four disease groups that have an immune component involved in their pathology
List the cells and proteins involved in eliciting an immune response
Understand the different mechanisms by which the immune response responds to and eradicates infectious agents from the body
List four approaches for generating vaccines
Explain how the immune system can be manipulated to treat autoimmune diseases
List five common autoimmune diseases

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